Acquired Hemophilia-A Mimicking Trauma-induced Coagulopathy in a Young Polytrauma Patient

Andrea Capponi*

Trauma-induced coagulopathy (TIC) is a common early complication in major trauma, typically presented with prolonged PT and aPTT. However, isolated or disproportionate aPTT prolongation warrants consideration of alternative diagnoses, such as acquired hemophilia A, a rare autoimmune disorder marked by factor VIII inhibitors and severe bleeding. This case describes a young, previously healthy trauma patient whose presentation mimicked TIC but was ultimately diagnosed with acquired hemophilia A, requiring immunosuppressive therapy and bypassing agents. The case underscores the importance of maintaining a broad differential diagnosis for coagulopathy in trauma settings to ensure timely recognition and appropriate management of rare but life-threatening conditions.

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Published on: Nov 12, 2025 Pages: 7-10

Full Text PDF Full Text HTML DOI: 10.17352/ac.000026
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