Sex-determining region y (SRY)-Box2 (SOX2) & L1-cell adhesion molecule (L1CAM) expressions in endometrioid carcinoma of the uterus; An Immunohistochemical Study

Amir M Salem* and Entsar R Mahdy

Background: activation of cancer stem cells and disturbances in cell adhesion pathways are recently incriminated in endometrioid carcinoma progression, invasion and metastases which consequently leads to dismal patients outcome. Sex-determining region y (SRY)-Box2 (SOX2) is a member of SOX family and it has many roles in malignant stem cells control. L1-cell adhesion molecule (L1CAM) is a membrane glycoprotein which is a member of immunoglobulin family. 

The aim of the work: is to evaluate prognostic, clinical and pathological values of Sox2& L1CAM expression in tissues of endometrioid carcinoma of the uterus.

Patients and methods: Sox2& L1CAM tissue protein expression was assessed by immunohistochemistry in sections from sixty paraffin blocks which are retrieved from 60 patients with endometrioid carcinoma of the uterus then correlations between their levels of expression, clinical, pathological data, progression and recurrence of the tumor and patients outcome were analyzed..

Results: SOX-2 expression in endometrioid carcinoma was associated with old age of the patient (p=0.003), larger tumor size(p=0.004), higher grade, advanced stage, presence of L.N and distant metastases (p<0.001), presence of myometrial invasion, cervical stromal invasion (p=0.006), lymphovascular (p=0.02) & parametrial (p=0.007), serosal (p=0.03), and adnexal invasions (p=0.008), shorter 5-year overall survival rate (p=0.003), and shorter 5-year disease free survival rate (p=0.005).

L1CAM expression in endometrioid carcinoma was associated with larger tumor size (p=0.017), higher grade (p=0.0 43),, advanced stage(p=0.0 31), presence of L.N (p=0.0 33), and distant metastases(p=0.0 49), presence of myometrial invasion (p=0.0 27), cervical stromal invasion (p=0.026), lymphovascular (p=0.02) & parametrial (p=0.012), serosal (p=0.042), and adnexal invasions (p=0.034), shorter 5-year overall survival rate (p=0.002), and shorter 5-year disease free survival rate (p=0.006). We found a positive relationship between SOX-2 and L1CAM r (Correlation Coefficient) = +0.735 (P<0.001).

Conclusion: Sox-2& L1CAM expression correlates with poor clinicopathological parameters of endometrioid carcinoma

Keywords: Sox-2; L1CAM; Endometrioid carcinoma; Grade; Immunohistochemistry

Published on: Aug 9, 2018 Pages: 1-8

Full Text PDF Full Text HTML DOI: 10.17352/acp.000010
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