The association between tumor microenvironment collagen and liver metastasis in colorectal cancer

Jiawen Fan, Qing Zhu, Jianming Nie and J Dinghua Yang*

The colon is an organ rich in collagen, while the liver is an organ deficient in collagen. The tissue microenvironment of the two organs differs significantly, but the incidence of liver metastasis in colorectal cancer is high. Besides vascular drainage factors, the changes in collagen occurring in the liver during the process of colorectal cancer liver metastasis are also very important. This article aims to discuss the characteristics of collagen changes in the premetastatic stage, liver colonization, and intrahepatic metastasis process of colorectal cancer liver metastasis.

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Published on: May 7, 2024 Pages: 13-19

Full Text PDF Full Text HTML DOI: 10.17352/acp.000031
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