Stevens-Johnson syndrome due to Lamotrigine

Silvio Espínola*

Lamotrigine is an anticonvulsant drug that has been widely used to treat epilepsy, as a mood stabilizer (in cases of bipolar type 1 disorder), and in the management of neuropathic pain; It is used both in monotherapy and in complementary therapy. Considered a relatively new medication, approved by the Food and Drug Administration in 1994, its benefits include a greater margin of safety compared to other anticonvulsants; However, it causes serious adverse skin reactions, such as Stevens-Johnson syndrome. Approximately 8% of patients receiving lamotrigine develop a benign maculopapular rash during the first 4 months of treatment. A case of Stevens-Johnson syndrome caused by the drug is presented and a review of the condition and the probable pathways that trigger this delayed hypersensitivity immune response is carried out.

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Published on: Jul 27, 2024 Pages: 1-5

Full Text PDF Full Text HTML DOI: 10.17352/2455-8141.000027
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