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Testimonial

Basic Medical Sciences

Annals of Molecular and Genetic Medicine

ISSN: 2692-4595

Executive Editor(s)

Wei Wu

China

Dr. Wei Wu is an Associate Professor and Associate Department Chair in the Department of Toxicology at Nanjing Medical University, China, where he received his Ph.D. in Toxicology in 2012. He was a guest researcher at the National Institute of Environmental Health Sciences (NIEHS) between 2017 and 2018.
He is a member of different national and international societies in the fields of human reproduction and toxicology, and has received awards from many national societies for the originality and quality of his projects. He has a wide range of teaching and consulting experience, including in the area of toxicology. His research interests include epigenetic mechanisms of transgenerational effects of male infertility induced by endocrine disrupting chemicals, environmental exposure, and male reproductive health, genetic and epigenetic risk factors of male infertility and abnormal fetal growth.
Prof. Wu has authored 72 peer-reviewed papers in international journals such as EBioMedicine, Clinical Epigenetics, Environment International, Toxicological Sciences, Scientific Reports, Human Reproduction, and Molecular Human Reproduction. He has edited four books and collaborated on ten books, 11 patents and in the organization of three international conferences. He is a reviewer of 62 journals. Prof. Wu serves as the Editor-in-Chief of an international scientific journal International Journal of Sexual Health and Reproductive Health Care, Executive Editor of Annals of Molecular and Genetic Medicine, Associate Editor of the JSM Invitro Fertilization, and editor of many other journals including Scientific Reports and Medicine.
Research Interest: Dr. Wei Wu research interests includes male reproductive health, reproductive toxicology, pregnancy complications, abnormal birth outcomes, epigenetics and fetal growth, genetics, polymorphism, reproductive epidemiology, and environmental epidemiology.

Grants:

1） Major Project of Natural Science Research in Jiangsu Province Colleges and Universities in 2020 (20KJA330001): the role of miR-206/Ehhadh in the intergenerational inheritance of spermatogenesis from exposure to pregnancy DBP and its mechanism ,2021/1-2023/12, ￥150,000.

2） Medical Research Project of Jiangsu Health and Health Commission (Z2019010): study on the mechanism of transgenerational inheritance of spermatogenesis induced by metabolic pathway changes in intrauterine DBP exposure 2020/1-2022/12, ￥10,000.

3） National key research and development project: The establishment and basic research for application of China Assisted reproductive birth cohort population and the offspring cohort of the Chinese population. 2016/7-2021/6, ￥280,900.

4） National Natural Science Foundation of China (81673217): The study of role and molecular mechanisms of the DSTF1/miR-125-3p/Fstl3 pathway in the transgenerational spermatogenic failure caused by prenatal DBP exposure. 2017/1-2020/12, ￥600,000.

5） China Postdoctoral Science Foundation (2015T80571): The role and molecular mechanisms of human miR-483-3p in the BP-3 induced fetal macrosomia. 2015/7-2017/6, ￥150,000.

6） National Natural Science Foundation of China (81302457): Effect and mechanism of miR-17-92 gene cluster in spermatogenic failure induced by genistein exposure. 2014/1-2016/12, ￥240,000.

7） Jiangsu Natural Science Foundation (BK20130894): The role and molecular mechanisms of miR-200s family in spermatogenic failure induced by genistein exposure. 2013/7-2016/6, ￥200,000.

8） China Postdoctoral Science Foundation (2013M531388): The role and molecular mechanism of imprinted lncRNA-H19 in fetal growth restriction. 2013/3-2015/2, ￥50,000.

9） Science and Technology Development Fund Key Project of Nanjing Medical University (2012NJMU002): Environment and epigenetics risk factors and their interactions in spermatogenic failure. 2012/12-2014/12, ￥30,000.

List of Publications:

1）    Guan Q, Chen S, Wang B, Dou X, Lu Y, Liang J, Ni R, Yang C, Wang H, Baktash MB, Wu W, Wang X, Fu G, Xia Y. Effects of particulate matter exposure on semen quality: A retrospective cohort study. Ecotoxicol Environ Saf. 2020; 193:110319.
2）    Yuan B, Wu W, Zhang H, Gu H, Guo D, Jiang J, Wang X. Adenomatous polyposis coli as a predictor of environmental chemical-induced transgenerational effects related to male infertility. J Biochem Mol Toxicol. 2019 Jul;33(7):e22331.
3）    Tang Q, Gui J, Wu X, Wu W*. Downregulation of miR-424 in placenta is associated with severe preeclampsia. Pregnancy Hypertens. 2019; 17:109-112.
4）    Tang Q, Pan F, Wu X, Nichols CE, Wang X, Xia Y, London SJ, Wu W*. Semen quality and cigarette smoking in a cohort of healthy fertile men. Environ Epidemiol. 2019; (32019)3:e055.
5）    Han X, Wang Y, Chen T, Wilson MJ, Pan F, Wu X, Rui C, Chen D, Tang Q, Wu W*. Inhibition of progesterone biosynthesis induced by deca-brominated diphenyl ether (BDE-209) in mouse Leydig tumor cell (MLTC-1). Toxicol In Vitro. 2019; 60:383-388.
6）    Guo D, Jiang H, Chen Y, Yang J, Fu Z, Li J, Han X, Wu X, Xia Y, Wang X, Chen L, Tang Q, Wu W*. Elevated microRNA-141-3p in placenta of non-diabetic macrosomia regulate trophoblast proliferation. EBioMedicine. 2018; 38:154-161. (Cover Article)
7）    Tang Q, Pan F, Yang J, Fu Z, Lu Y, Wu X, Han X, Chen M, Lu C, Xia Y, Wang X, Wu W*. Idiopathic male infertility is strongly associated with aberrant DNA methylation of imprinted loci in sperm: a case-control study. Clin Epigenetics. 2018; 10(1):134.
8）    Li J, Fu Z, Jiang H, Chen L, Wu X, Ding H, Xia Y, Wang X, Tang Q, Wu W*. IGF2-derived miR-483-3p contributes to macrosomia through regulating trophoblast proliferation by targeting RB1CC1. Mol Hum Reprod. 2018; 24(9):444-452.
9）    Zhou R, Zhang Y, Du G, Han L, Zheng S, Liang J, Huang X, Qin Y, Wu W, Chen M, Wu D, Song L, Fu G, Lv S, Xia Y, Lu C, Wang X. Down-regulated let-7b-5p represses glycolysis metabolism by targeting AURKB in asthenozoospermia. Gene. 2018; 663:83-87.
10）    Chen M, Ni C, Hu Y, Wang M, Liu L, Ji X, Chu H, Wu W, Lu C, Wang S, Wang S, Zhao L, Li Z, Zhu H, Wang J, Xia Y, Wang X. Meta-analysis on the effectiveness of team-based learning on medical education in China. BMC Med Educ. 2018;18(1):77.
11）    Han Y, Ji Y, Kang S, Dong T, Zhou Z, Zhang Y, Chen M, Wu W, Tang Q, Chen T, Wang Y, Xia Y. Effects of particulate matter exposure during pregnancy on birth weight: A retrospective cohort study in Suzhou, China. Sci Total Environ. 2018; 615:369-374.
12）    Yuan B, Wu W*, Chen M, Gu H, Tang Q, Guo D, Chen T, Chen Y, Lu C, Song L, Xia Y, Chen D, Rehan V, Sha J, Wang X*. Metabolomics reveals a role of betaine in prenatal DBP exposure-induced epigenetic transgenerational failure of spermatogenesis in rats. Toxicol Sci. 2017; 158 (2): 356-366. (Cover Article)
13）    Tang Q, Chen Y, Wu W*, Ding H, Xia Y, Chen D, Wang X. Idiopathic male infertility and polymorphisms in the DNA methyltransferase genes involved in epigenetic marking. Sci Rep. 2017; 7(1):11219.
14）    Wang L, Hu W, Guan Q, Du G, Chen T, Wu W, Wang Y, Wang X, Xia Y. The association between cooking oil fume exposure during pregnancy and birth weight: A prospective mother-child cohort study. Sci Total Environ. 2017; 612:822-830.
15）    Qiao S, Wu W (co-first author), Chen M, Tang Q, Xia Y, Jia W, Wang X. Seminal plasma metabolomics approach for the diagnosis of unexplained male infertility. PLoS One. 2017; 12(8):e0181115.
16）    Hu W, Chen M, Ji J, Qin Y, Zhang F, Xu M, Wu W, Du G, Wu D, Han X, Jin L, Xia Y, Lu C, Wang X. Interaction between Y chromosome haplogroup O3* and 4-n-octylphenol exposure reduces the susceptibility to spermatogenic impairment in Han Chinese. Ecotoxicol Environ Saf. 2017; 144:450-455.
17）    Pan L, Liu Q, Li J, Wu W, Wang X, Zhao D, Ma J. Association of the VDAC3 gene polymorphism with sperm count in Han-Chinese population with idiopathic male infertility. Oncotarget. 2017; 8(28):45242-45248.
18）    Chang C, Chen M, Gao J, Luo J, Wu K, Dong T, Zhou K, He X, Hu W, Wu W, Lu C, Hang B, Meeker JD, Wang X, Xia Y. Current pesticide profiles in blood serum of adults in Jiangsu Province of China and a comparison with other countries. Environ Int. 2017; 102:213-222.
19）    Gu H, Wu W*, Yuan B, Tang Q, Guo D, Chen Y, Xia Y, Hu L, Chen D, Sha J, Wang X. Genistein up-regulates miR-20a to disrupt spermatogenesis via targeting Limk1. Oncotarget. 2017; 8(35):58728-58737.
20）    Guo D, Wu W*, Tang Q, Qiao S, Chen Y, Chen M, Teng M, Lu C, Ding H, Xia Y, Hu L, Chen D, Sha J, Wang X. The impact of BMI on sperm parameters and the metabolite changes of seminal plasma concomitantly. Oncotarget. 2017; 8(30):48619-48634.
21）    Chen T, Xu J, Liu G, Liu H, Chen M, Qin Y, Wu W, Xia Y, Ji C, Guo X, Wen J, Wang X. Genetic variants in PTPRD and risk of gestational diabetes mellitus. Oncotarget. 2016; 7(46):76101-76107.
22）    Ji J, Qin Y, Zhou R, Zang R, Huang Z, Zhang Y, Chen M, Wu W, Song L, Ling X, Shen H, Hu Z, Xia Y, Lu C, Wang X. X chromosome-wide identification of SNVs in microRNA genes and non-obstructive azoospermia risk in han chinese population. Oncotarget. 2016; 7(31):49122-49129.
23）    Chang J, Pan F, Tang Q, Wu W*, Chen M, Lu C, Ding H, Hu L, Chen D, Xia Y, Wang X. eNOS gene T786C, G894T and 4a4b polymorphisms and male infertility susceptibility: a meta-analysis. Andrologia. 2016; 49(4).
24）    Hu W, Chen M, Wu W*, Lu J, Zhao D, Pan F, Lu C, Xia Y, Hu L, Chen D, Sha J, Wang X. Gene-gene and gene-environment interactions on risk of male infertility: Focus on the metabolites. Environ Int. 2016; 91:188-195.
25）    Pan B, Li R, Chen Y, Tang Q, Wu W*, Chen L, Lu C, Pan F, Ding H, Xia Y, Hu L, Chen D, Sha J, Wang X. Genetic Association Between Androgen Receptor Gene CAG Repeat Length Polymorphism and Male Infertility: A Meta-Analysis. Medicine (Baltimore). 2016; 95(10):e2878.
26）    Yuan B, Gu H, Xu B, Tang Q, Wu W*, Ji X, Xia Y, Hu L, Chen D, Wang X. Effects of Gold Nanorods on Imprinted Genes Expression in TM-4 Sertoli Cells. Int J Environ Res Public Health. 2016; 13(3). pii: E271.
27）    Lu J, Gu H, Tang Q, Wu W*, Yuan B, Guo D, Wei Y, Sun H, Xia Y, Ding H, Hu L, Chen D, Sha J, Wang X. Common SNP in hsa-miR-196a-2 increases hsa-miR-196a-5p expression and predisposes to idiopathic male infertility in Chinese Han population. Sci Rep. 2016; 6:19825.
28）    Zhou R, Wang R, Qin Y, Ji J, Xu M, Wu W, Chen M, Wu D, Song L, Shen H, Sha J, Miao D, Hu Z, Xia Y, Lu C, Wang X. Mitochondria-related miR-151a-5p reduces cellular ATP production by targeting CYTB in asthenozoospermia. Sci Rep. 2015; 5:17743.
29）    Li J, Chen L, Tang Q, Wu W*, Gu H, Liu L, Wu J, Jiang H, Ding H, Xia Y, Chen D, Hu Y, Wang X. The role, mechanism and potentially novel biomarker of microRNA-17-92 cluster in macrosomia. Sci Rep. 2015; 5:17212.
30）    Ji J, Qin Y, Ren J, Lu C, Wang R, Dai X, Zhou R, Huang Z, Xu M, Chen M, Wu W, Song L, Shen H, Hu Z, Miao D, Xia Y, Wang X. Mitochondria-related miR-141-3p contributes to mitochondrial dysfunction in HFD-induced obesity by inhibiting PTEN. Sci Rep. 2015; 5:16262.
31）    Ju R, Wu W (co-first author), Tang Q, Wu D, Xia Y, Wu J, Wang X. Association Analysis between the Polymorphisms of HSD11B1 and H6PD and Risk of Polycystic Ovary Syndrome in Chinese Population. PLoS One. 2015; 10(10):e0140326.
32）    Lu C, Xu M, Wang R, Qin Y, Ren J, Wu W, Song L, Wang S, Zhou Z, Shen H, Sha J, Hu Z, Xia Y, Miao D, Wang X. A genome-wide association study of mitochondrial DNA in Chinese men identifies two risk single nucleotide substitutions for idiopathic oligoasthenospermia. Mitochondrion. 2015; 24:87-92.
33）    Tang W, Tang J, He J, Zhou Z, Qin Y, Qin J, Li B, Xu X, Geng Q, Jiang W, Wu W, Wang X, Xia Y. SLIT2/ROBO1-miR-218-1-RET/PLAG1: a new disease pathway involved in Hirschsprung's disease. J Cell Mol Med. 2015; 19(6):1197-207.
34）    Ju R, Wu W (co-first author), Fei J, Qin Y, Tang Q, Wu D, Xia Y, Wu J, Wang X. Association analysis between the polymorphisms of HSD17B5 and HSD17B6 and risk of polycystic ovary syndrome in Chinese population. Eur J Endocrinol. 2015; 172(3):227-33.
35）    Tang W, Li H, Tang J, Wu W, Qin J, Lei H, Cai P, Huo W, Li B, Rehan V, Xu X, Geng Q, Zhang H, Xia Y. Specific serum microRNA profile in the molecular diagnosis of Hirschsprung's disease. J Cell Mol Med. 2014; 18(8):1580-7.
36）    Zhao M, Tang Q, Wu W (corresponding author), Xia Y, Chen D, Wang X. miR-20a contributes to endometriosis by regulating NTN4 expression. Mol Biol Rep. 2014; 41(9):5793-7.
37）    Jiang H, Wu W (co-first author), Zhang M, Li J, Peng Y, Miao T, Zhu H, Xu G. Aberrant upregulation of miR-21 in placental tissues of macrosomia. J Perinatol. 2014; 34(9):658-63.
38）    Zhang S, Tang Q, Wu W*, Yuan B, Lu C, Xia Y, Ding H, Hu L, Chen D, Sha J, Wang X. Association between DAZL polymorphisms and susceptibility to male infertility: systematic review with meta-analysis and trial sequential analysis. Sci Rep. 2014; 4:4642.
39）    Qin Y, Ji J, Du G, Wu W, Dai J, Hu Z, Sha J, Hang B, Lu C, Xia Y, Wang X. Comprehensive pathway-based analysis identifies associations of BCL2, GNAO1 and CHD2 with non-obstructive azoospermia risk. Hum Reprod. 2014; 29(4):860-6.
40）    Qin Y, Du G, Chen M, Hu W, Lu C, Wu W, Hang B, Zhou Z, Wang X, Xia Y. Combined effects of urinary phytoestrogens metabolites and polymorphisms in metabolic enzyme gene on idiopathic male infertility. Arch Toxicol. 2014; 88(8):1527-36.
41）    Zhou Z, Qin J, Tang J, Li B, Geng Q, Jiang W, Wu W, Rehan V, Tang W, Xu X, Xia Y. Down-regulation of MeCP2 in Hirschsprung's disease. J Pediatr Surg. 2013; 48(10):2099-2105.
42）    Tang W, Qin J, Tang J, Zhang H, Zhou Z, Li B, Geng Q, Wu W, Xia Y, Xu X. Aberrant reduction of MiR-141 increased CD47/CUL3 in Hirschsprung's disease. Cell Physiol Biochem. 2013; 32(6):1655-67.
43）    Xu M, Qin Y, Qu J, Lu C, Wang Y, Wu W, Song L, Wang S, Chen F, Shen H, Sha J, Hu Z, Xia Y, Wang X. Evaluation of Five Candidate Genes from GWAS for Association with Oligozoospermia in a Han Chinese Population. PLoS One. 2013; 8(11):e80374.
44）    Lu C, Xu M, Wang R, Qin Y, Wang Y, Wu W, Song L, Wang S, Shen H, Sha J, Miao D, Hu Z, Xia Y, Wang X. Pathogenic variants screening in five non-obstructive azoospermia-associated genes. Mol Hum Reprod. 2013; 20(2):178-83.
45）    Tang Q, Li J, Zhang S, Yuan B, Sun H, Wu D, Lu C, Wu W (corresponding author), Xia Y, Ding H, Hu L, Chen D*, Sha J*, Wang X. GSTM1 and GSTT1 Null Polymorphisms and Childhood Acute Leukemia Risk: Evidence from 26 Case-Control Studies. PLoS One. 2013; 8(10):e78810.
46）    Xu S, Xu P, Wu W, Ou Y, Xu J, Zhang G, Li J, Xu G. The biphasic expression pattern of miR-200a and E-cadherin in epithelial ovarian cancer and its correlation with clinicopathological features. Curr Pharm Des. 2014; 20(11):1888-95.
47）    Wu W*, Lu J, Tang Q, Zhang S, Yuan B, Li J, Di Wu, Sun H, Lu C, Xia Y, Chen D, Sha J, Wang X. GSTM1 and GSTT1 null polymorphisms and male infertility risk: an updated meta-analysis encompassing 6934 subjects. Sci Rep. 2013; 3:2258.
48）    Xu C, Song RJ, Yang J, Jiang B, Wang XL, Wu W, Zhang W. Klotho gene polymorphism of rs3752472 is associated with the risk of urinary calculi in the population of Han nationality in Eastern China. Gene. 2013; 526(2):494-7.
49）    Lu C, Wang Y, Zhang F, Lu F, Xu M, Qin Y, Wu W, Li S, Song L, Yang S, Wu D, Jin L, Shen H, Sha J, Xia Y, Hu Z, Wang X. DAZ duplications confer the predisposition of Y chromosome haplogroup K* to non-obstructive azoospermia in Han Chinese populations. Hum Reprod. 2013; 28(9):2440-9.
50）    Wu W*, Lu J, Chen D, Yuan B, Qin Y, Han X, Niu X, Xu B, Lu C, Xia Y, Sha J, Wang X. Association of prostate cancer susceptibility variant (MSMB) rs10993994 with risk of spermatogenic failure. Gene. 2013; 524:197-202.
51）    Tang W, Li B, Tang J, Liu K, Qin J, Wu W, Geng Q, Zhang J, Chen H, Xu X, Xia Y. Methylation analysis of EDNRB in human colon tissues of Hirschsprung's disease. Pediatr Surg Int. 2013; 29:683-8.
52）    Lv Q, Lu J, Wu W, Sun H, Zhang J. Association of the methylenetetrahydrofolate reductase gene A1298C polymorphism with stroke risk based on a meta-analysis. Genet Mol Res. 2013; 12(4):6882-94.
53）    Wu W, Qin Y, Li Z, Dong J, Dai J, Lu C, Guo X, Zhao Y, Zhu Y, Zhang W, Sha J, Shen H, Xia Y, Hu Z, Wang X. Genome-wide microRNA expression profiling in idiopathic non-obstructive azoospermia: significant up-regulation of miR-141, miR-429 and miR-7-1-3p. Hum Reprod. 2013; 28:1827-36.
54）    Qin Y, Chen M, Wu W (co-first author), Xu B, Tang R, Chen X, Du G, Lu C, Meeker JD, Zhou Z, Xia Y, Wang X. Interactions between Urinary 4-tert-Octylphenol Levels and Metabolism Enzyme Gene Variants on Idiopathic Male Infertility. PLoS One. 2013; 8:e59398.
55）    Tang Q, Wu W (co-first author), Xu X, Huang L, Gao Q, Chen H, Sun H, Xia Y, Sha J, Wang X, Chen D, Xu Q. miR-141 Contributes to Fetal Growth Restriction by Regulating PLAG1 Expression. PLoS One. 2013; 8:e58737.
56）    Lu C, Xu M, Wang Y, Qin Y, Du G, Wu W, Han X, Ji C, Yang Y, Gu A, Xia Y, Song L, Wang S, Wang X. Genetic variants in meiotic program initiation pathway genes are associated with spermatogenic impairment in a Han Chinese population. PLoS One. 2013; 8:e53443.
57）    Xu S, Wu W (co-first author), Sun H, Lu J, Yuan B, Xia Y, Moor B, Marchal K, Wang X, Xu P, Cheng W. Association of the vascular endothelial growth factor gene polymorphisms (-460C/T, +405G/C, and +936T/C) with endometriosis: a meta-analysis. Ann Hum Genet. 2012; 76:464-471.
58）    Chen M, Xu B, Ji W, Qiao S, Hu N, Hu Y, Wu W, Qiu L, Zhang R, Wang Y, Wang S, Zhou Z, Xia Y, Wang X. Bisphenol A Alters n-6 Fatty Acid Composition and Decreases Antioxidant Enzyme Levels in Rat Testes: A LC-QTOF-Based Metabolomics Study. PLoS One. 2012; 7:e44754.
59）    Tang W, Li B, Xu X, Zhou Z, Wu W, Tang J, Qin J, Geng Q, Jiang W, Zhang J, Sha J, Xia Y, Wang X. Aberrant high expression of NRG1 gene in Hirschsprung disease. J Pediatr Surg. 2012; 47:1694-8.
60）    Han X, Tang R, Chen X, Xu B, Qin Y, Wu W, Hu Y, Xu B, Song L, Xia Y, Wang X. 2,2',4,4'-Tetrabromodiphenyl ether (BDE-47) decreases progesterone synthesis through cAMP-PKA pathway and P450scc downregulation in mouse Leydig tumor cells. Toxicology. 2012; 302:44-50.
61）    Zhao D, Wu W (co-first author), Xu B, Niu X, Cui H, Zhang Y, Wang Z, Wang X. Variants in the SRD5A2 gene are associated with quality of semen. Mol Med Report. 2012; 6:639-44.
62）    Wu W, Hu Z, Qin Y, Dong J, Dai J, Lu C, Zhang W, Shen H, Xia Y, Wang X. Seminal plasma microRNAs: potential biomarkers for spermatogenesis status. Mol Hum Reprod. 2012; 18:489-97.
63）    Wu W, Cai H, Sun H, Lu J, Zhao D, Qin Y, Han X, Niu X, Lu C, Xia Y, Wang S, De Moor B, Marchal K, Wang X. Follicle stimulating hormone receptor G-29A, 919A>G, 2039A>G polymorphism and the risk of male infertility: A meta-analysis. Gene. 2012; 505:388-92.
64）    Qin Y, Xia Y, Wu W, Han X, Lu C, Ji G, Chen D, Wang H, Song L, Wang S, Wang X. Genetic variants in microRNA biogenesis pathway genes are associated with semen quality in a Han-Chinese population. Reprod Biomed Online. 2012; 24:454-61.
65）    Shen O, Liu R, Wu W (co-first author), Yu L, Wang X. Association of the methylenetetrahydrofolate reductase gene A1298C polymorphism with male infertility: a meta-analysis. Ann Hum Genet. 2012; 76:25-32.
66）    Lu C, Zhang F, Yang H, Xu M, Du G, Wu W, An Y, Qin Y, Ji G, Han X, Gu A, Xia Y, Song L, Wang S, Jin L, Wang X. Additional genomic duplications in AZFc underlie the b2/b3 deletion-associated risk of spermatogenic impairment in Han Chinese population. Hum Mol Genet. 2011; 20:4411-21.
67）    Shen O, Wu W (co-first author), Du G, Liu R, Yu L, Sun H, Han X, Jiang Y, Shi W, Hu W, Song L, Xia Y, Wang S, Wang X. Thyroid Disruption by Di-n-Butyl Phthalate (DBP) and Mono-n-Butyl Phthalate (MBP) in Xenopus laevis. PLoS One. 2011; 6:e19159.
68）    Wu W, Shen O, Qin Y, Lu J, Niu X, Zhou Z, Lu C, Xia Y, Song L, Wang S, Wang X. Methylenetetrahydrofolate reductase C677T polymorphism and the risk of male infertility: a meta-analysis. Int J Androl. 2012; 35:18-24.
69）    Wu W, Shen O, Qin Y, Niu X, Lu C, Xia Y, Song L, Wang S, Wang X. Idiopathic Male Infertility Is Strongly Associated with Aberrant Promoter Methylation of Methylenetetrahydrofolate Reductase (MTHFR). PLoS One. 2010; 5: e13884.
70）    Wu W, Lu C, Xia Y, Shen O, Ji G, Gu A, Song L, Wang X. Lack of association between DAZ gene methylation patterns and spermatogenic failure. Clin Chem Lab Med. 2010; 48: 355-60.
71）    Shen O, Du G, Sun H, Wu W, Jiang Y, Song L, Wang X. Comparison of in vitro hormone activities of selected phthalates using reporter gene assays. Toxicol Lett. 2009; 191: 9-14.
72）    Lu C, Zhang J, Li Y, Xia Y, Zhang F, Wu B, Wu W, Ji G, Gu A, Wang S, Jin L, Wang X. The b2/b3 subdeletion shows higher risk of spermatogenic failure and higher frequency of complete AZFc deletion than the gr/gr subdeletion in a Chinese population. Hum Mol Genet. 2009; 18:1122-30.

More Info.

Feng Jiang

USA

My journey in conducting biological research began during my undergraduate when I had a chance to work in Dr. Min Wu’s lab in Wuhan University, China to study a potential cancer casual genetic variant in cultured cells. This experience ignited my passion to pursue a long-term career in research. Eager to expand my horizons, I applied for graduate school immediately after undergraduate and joined the Ph.D. program in Biochemistry and Molecular Biology at University of Rochester. I began my Ph.D. research in Dr. Peng Yao’s lab focusing on the role of RNA-binding proteins in RNA processing. It was during this time I realized how my work could be enriched by employing powerful high-throughput sequencing techniques and bioinformatic analysis. Motivated by this realization, I began learning both the experimental and analytical aspects of sequencing techniques. I was later granted a sabbatical in Dr. Lai Wei’s lab in Yat-sen University, China, where I accumulated enough knowledge and experience regarding sequencing analysis. Levering this knowledge, I established a bioinformatic branch upon returning to the Yao Lab and applied sequencing to all projects in the lab, analyzing sequencing data generated by myself and collaborators. After completing my Ph.D. Therefore, I joined as a postdoctoral researcher in Dr. Jin Billy Li’s lab at Stanford University, where I will combine my knowledge in the field of RNA biology and bioinformatic skills to study the dsRNA processing, specifically, editing, in autoimmune diseases.

Research Interest: RNA biology, mRNA translation, RNA editing, cardiovascular diseases, microRNA, antisense oligonucleotides

Publication List:

Jiang, F., Hedaya, O.M., Khor, E., Wu, J., Auguste, M., & Yao, P. (2023). RNA binding protein PRRC2B mediates translation of specific mRNAs and regulates cell cycle progression. Nucleic Acids Research, 51(11), 5831–5846.
Hedaya, O.M., Venkata Subbaiah, K.C., Jiang, F., Xie, L.H., Wu, J., Khor, E.-S., Zhu, M., Mathews, D.H., Proschel, C., and Yao, P. (2023). Secondary structures that regulate mRNA translation provide insights for ASO-mediated modulation of cardiac hypertrophy. Nature Communications 14, 6166.
Wu, J., Subbaiah, K.C.V., Jiang, F., Hedaya, O., Mohan, A., Yang, T., Welle, K., Ghaemmaghami, S., Tang, W.H.W., Small, E., Yan, C., & Yao, P. (2021). MicroRNA-574 regulates FAM210A expression and influences pathological cardiac remodeling. EMBO Molecular Medicine, 13, e12710.
Wu, J., Subbaiah, K.C.V., Xie, L.H., Jiang, F., Khor, E.-S., Mickelsen, D., Myers, J.R., Tang, W.H.W., & Yao, P. (2020). Glutamyl-Prolyl-tRNA Synthetase Regulates Proline-Rich Pro-Fibrotic Protein Synthesis During Cardiac Fibrosis. Circulation Research, 127, 827-846.
Subbaiah, K.C.V., Hedaya, O., Wu, J., Jiang, F., & Yao, P. (2019). Mammalian RNA switches: Molecular rheostats in gene regulation, disease, and medicine. Computational and Structural Biotechnology Journal, 17, 1326-1338.
Sun, Y.H., Jiang, F., & Li, X.Z. (2018). Disruption of Tdrd5 decouples the stepwise processing of long precursor transcripts during pachytene PIWI-interacting RNA biogenesis. Biology of Reproduction, 99, 684-685.
He, W., Zhang, F., Jiang, F., Liu, H. & Wang, G. Correlations between serum levels of microRNA-148a-3p and microRNA-485-5p and the progression and recurrence of prostate cancer. BMC Urology 22, 195, doi:10.1186/s12894-022-01143-z (2022).
Li, W., Li, Y., Jiang, F. & Liu, H. Correlation between serum levels of microRNA-21 and inflammatory factors in patients with chronic heart failure. Medicine 101 (2022).
Meng, F., Chen, P., Guo, X., Li, X., Wu, Y., Liu, W., Jiang, F., Liu, H. and Wang, L. (2021) Correlations between Serum P2X7, Vitamin A, 25-hydroxy Vitamin D, and Mycoplasma Pneumoniae Pneumonia. Journal of Clinical Laboratory Analysis, 35, e23760.
Wu, J., Hollinger, J., Bonanno, E., Jiang, F. & Yao, P. Cardiomyocyte-Specific Loss of Glutamyl-prolyl-tRNA Synthetase Leads to Disturbed Protein Homeostasis and Dilated Cardiomyopathy. Cells 13 (2024).
Xia, G., Li, X., Shang, Y., Fu, B., Jiang, F., Liu, H. and Qiao, Y. (2021) Correlation between severity of spinal stenosis and multifidus atrophy in degenerative lumbar spinal stenosis. BMC Musculoskeletal Disorders, 22, 536
Zhu, X., Li, K., Zheng, J., Xia, G., Jiang, F., Liu, H. and Shi, J. (2022) Usage of procalcitonin and sCD14-ST as diagnostic markers for postoperative spinal infection. Journal of Orthopaedics and Traumatology, 23, 25.

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Ji Youn Lee

USA

I got a Ph.D. degree (Radiology) at Seoul National University, which is Top of University in Korea, and got a Post Doc training in the Department of Radiology at University of Pennsylvania. To date, my studies have focused on the development of new biomarkers for diagnosis& therapeutic approach, and evaluation their ability by in vitro and in vivo experiments related with tumor and neuroscience. These day, I’m working to learn about a new therapeutic approach using alpha and beta emitted radioisotope labeled biomarker, quality control, drug formulation and stability.

Research Interest: I am an expert in the fields of molecular imaging (PET, SPECT, CT, MRI, IVIS, microscope, confocal image), CDX modelling, radio-isotope related research, set up the assay protocol (Kd, Bmax, Ki), drug screening, validation of new biomarker by in vitro assay and in vivo experiments, ADME, and analysis of data. It was provided by peer-reviewed paper publication on molecular biology, radiology, and neuroscience fields. I’m interested in the development of new biomarkers for diagnosis and therapy, the binding mechanism of biomarkers, understanding pharmacological profiles of biomarkers, and estimating possibility of therapeutic use for clinical approach. Based on expanding skills and knowledge, I would like to contribute in the field of the development of new biomarkers for diagnosis and therapy by in vitro and in vivo studies.

Publications List:

Ji Youn Lee, et all. “In vitro characterization of [125I]HY-3-24, a selective ligand for the dopamine D3 receptor” March 2024, Accepted in Frontiers In Neuroscience.
Gui-Long Tian, Chia-Ju Hsieh, Michelle Taylor, Ji Youn Lee, et all. “Synthesis of bitopic ligands based on fallypride and evaluation of their affinity and selectivity towards dopamine D2 and D3 receprots” Eur J Med Chem 2023 Dec 261:115751.
Kim, Ho Young; Lee, Ji Youn, et all. “Design and synthesis of conformationally-flexible scaffold based bitopic ligands for potent D3 selective antagonists" Int J Mol Sci 2022 Dec;24(1):432.
Mehran Makvandi, Minu Samanta, Paul Martorano, Hwan Lee, Sarah Gitto, Khusbu Patel, David Groff, Jennifer Pogoriler, Daniel Martinez, Aladin Riad, Hannah Dabagian, Michael Zaleski, Tahereh Taghvaee, Kuiying Xu, Ji Youn Lee, et all. “Pre-clinical investigation of astatine-211-parthanatine for high-risk neuroblastoma” Communication Biology, 2022 Nov 5(1):1260.
Chia-Ju Hsieh, Catherine Hou, Yi Zhu, Ji Youn Lee, et all “[18F]ROStrace detects oxidative stress in ivo and predicts progression of Alzheimer’s disease pathology in APP/PS1 mice” EJMMI Res 2022 Jul 27;12(1):43.
Kuiying Xu, Chia-Ju Jsieh, Ji Youn Lee, et al “Exploration of Diazaspiro Cores as Piperazine Bioisosteres in the Development of σ2 Receptor Ligands” Int J Mol Sci. 2022 Jul 27;23(15):8259.
Kim, Ho Young; Lee, Ji Youn, et al. “Screening of σ2 receptor ligands and in vivo evaluation of 11C-labeled 6,7-dimethoxy-2-(4-(4-methoxyphenyl)butan-2-yl)-1,2,3,4-tetrahydroisoquinoline for potential use as σ2 receptor brain PET tracer" JMC. 2022,65;8:6261-6272.
Laura N Puentes, Zsofia Lengyel-Zhand, Ji Youn Lee, et al “Poly (ADP-ribose) induces α-synuclein aggregation in neuronal-like cells and interacts with phosphorylated α-synuclein in post mortem PD samples” Front Aging Neurosci. 2021 Jun 18;13:704041.
CJ Hsieh, A Riad, Ji Youn Lee, et al “Interaction of ligands for PET with the dopamine D3 receptor: In silico and In vitro methods” Biomolecules 2021 Apr 2;11(4), 529.
Xiao-Yang Xie, Yu-Yun Li, Wen-Hui Ma, Ai-fang Chen, Yu-Tong Sun, Ji Youn Lee, et al “Synthesis, inding, and functional properties of tetrahydroisoquinolino-2-alkyl phenones as selective sigma 2 /TMEM97 ligands” Eur J Med Chem. 2020;7;209;112906.
Ji Youn Lee, et al “Preparation of a multi-modal agent for sentinel lymph node mapping using Evans blue and 99mTc-labeled mannosylated human serum albumin conjugate” Nucl Med Biol. 2020;84-5:38-45.
Park JY, Kim YJ, Lee JY, et al “Imaging of the third gasotransmitter hydrogen sulfide using 99mTclabeled alpha-hydroxy acids” Nucl Med Biol. 2019;76-77:28-35.
Kim HY, Lee JY, et al “Design and synthesis of enantiopure 18F-labelled [18F]trifluoromethyltryptophan from 2-halotryptophan derivatives via copper(I)-mediated [18F]trifluoromethylation and evaluation of its in vitro characterization for the serotonergic system imaging.” J Labelled Comp Radiopharm. 2019;62(9);566-579.
Lee JY, et al “Naphthol Blue Black and 99mTc-Labeled Mannosylated Human Serum Albumin (99mTc-MSA) Conjugate as a Multimodal Lymph Node Mapping Nanocarrier” Sci Rep 2018;11;8(1);13636.
Kim HY, Park C, Lee JY, et al. “One-pot radiosynthesis of O-[(18)F]fluoromethyl-D-tyrosine via intra-molecular nucleophilic (18)F-fluorination with 1,2,3-triazolium triflate salt precursor.” Appl Radiat Isot. 2018;132:105-9.
Lee B, Kim YK, Lee JY, et al. “Preclinical anaylses of [(18)F]cEFQ as a PET tracer for imaging metabotropic glutamate receptor type 1 (mGluR1).” J Cereb Blood Flow Metab. 2017;37(6):2283-93. Seo HJ, Nam SH, Im HJ, Park JY, Lee JY, et al. “Rapid Hepatobiliary Excretion of icelleEncapsulated/Radiolabeled Upconverting Nanoparticles as an Integrated Form.” Sci Rep. 015;5:15685.
Seelam SR, Lee JY, et al. “Development of (68)Ga-labeled multivalent nitroimidazole derivatives for hypoxia imaging.” Bioorg Med Chem. 2015;23(24):7743-50.
Lee JY, et al. “Development of 68Ga-human serum albumin as a PET imaging agent for diagnosis of acute inflammation.” Journal of radiopharmaceuticals and molecular probes. 2015;1(2):104-8.
Lee JY, et al. “Preparation of Ga-68-NOTA as a renal PET agent and feasibility tests in mice.” Nucl Med Biol. 2014;41(2):210-5.
Shetty D, Jeong JM, Kim YJ, Lee JY, et al. “Development of a bifunctional chelating agent containing isothiocyanate residue for one step F-18 labeling of peptides and application for RGD labeling.” ioorg Med Chem. 2012;20(19):5941-7.
Hoigebazar L, Jeong JM, Lee JY, et al. “Syntheses of 2-nitroimidazole derivatives conjugated with 1,4,7-triazacyclononane-N,N'-diacetic acid labeled with F-18 using an aluminum complex method for hypoxia imaging.” J Med Chem. 2012;55(7):3155-62.
Hoigebazar L, Jeong JM, Hong MK, Kim YJ, Lee JY, et al. “Synthesis of 68Ga-labeled OTAnitroimidazole derivatives and their feasibilities as hypoxia imaging PET tracers.” Bioorg Med Chem. 2011;19(7):2176-81.
Shetty D, Choi SY, Jeong JM, Lee JY, et al. “Stable aluminium fluoride chelates with triazacyclononane derivatives proved by X-ray crystallography and 18F-labeling study.” Chem Comm. 2011;47(34):9732-4.
Shetty D, Jeong JM, Ju CH, Kim YJ, Lee JY, et al. “Synthesis and evaluation of macrocyclic amino acid derivatives for tumor imaging by gallium-68 positron emission tomography.” Bioorg Med Chem. 2010;18(21):7338-4.

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Anisa Iftikhar

USA

I am a Ph.D. candidate in Biosciences and Biotechnology at Clarkson University in Potsdam, New York, with an anticipated graduation date of May, 2026. So far, I have maintained a strong academic record with a CGPA of 3.556. Alongside my Ph.D. studies, I completed a Master of Philosophy degree in Biosciences and Biotechnology at Clarkson University in December 2023. My academic journey began in Pakistan, where I earned a Master of Philosophy in Zoology from the University of Lahore in Sargodha and a Bachelor of Science in Zoology from the University of Punjab in Lahore. I also hold a Bachelor of Education with a major in Leadership and Management from Allama Iqbal Open University in Islamabad.

Throughout my academic journey, I gained valuable teaching experience. I have been serving as a Teaching Assistant at Clarkson University since January 2023, where I teach labs for courses such as Cellular & Molecular Biology and Inheritance, Evolution, and Diversity. Before this, I worked as a Research Assistant at Clarkson University and held lecturer positions at the Excellence Group of Colleges and Times Group of Colleges in Pakistan. In addition to teaching, I am actively involved in peer reviewing several renowned journals, including the Journal of Applied Research in Plant Sciences, Pakistan Journal of Biotechnology, and Annual Research & Review in Biology, among others. I remain steadfast in my commitment to uphold scientific integrity and contribute to the dissemination of knowledge through these activities.

My expertise spans a broad spectrum of biochemistry, proteomics, and cell and molecular biology methods. These include chromatography, spectrophotometry, protein extraction, immunoprecipitation, SDS-PAGE, fluorescence microscopy, confocal microscopy, PCR, gel electrophoresis, CRISPR/Cas9, and other related techniques. Additionally, I am proficient in various computer applications, especially MS Office. I have presented my research at several international conferences and meetings, covering topics such as the ecology and behavior of ring-necked pheasants, insecticide resistance in cockroaches and house flies, and the ethics of xenotransplantation. My research findings have been published in prestigious journals addressing a wide range of topics, including pesticide exposure, embryotoxicity, and cryopreservation techniques.

I have been privileged to receive accolades and scholarships such as the CUSABIO Biology Scholarship and the National Science and Technology Council (NSTC) international internship pilot program. Moreover, I am a devoted member of several professional organizations and clubs, including the Muslim Student Association (MSA) and Pakistan Student Association (PSA). My ambition is to progress the field of bioscience and biotechnology through my research, teaching, and community services. My scientific journey motivated me, and I am devoted to contributing to substantial advancements and education in this area.

Research Interest: Stem Cells, CRISPR Cas 9, Genetics, Developmental Biology, Organogenesis

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Emil Bulatov

Russian Federation

2015 – PhD, University of Cambridge, UK

2010 – MPhil, Newcastle University, UK

Research Interest: Molecular and cell biology, immunology, oncology

Grants: Russian Foundation of Basic Research
(#16-34-60213; #16-34-50250; #17-34-50167; # 19-54-10005)

URL: https://kpfu.ru/emil.bulatov?p_lang=2

List of Publications:

Articles and conference abstracts
(2018) Article.
1. Emil Bulatov, Regina Sayarova, Rimma Mingaleeva, Regina Miftakhova, Marina Gomzikova, Yuri Ignatyev, Alexey Petukhov, Pavel Davidovich, Albert Rizvanov and Nickolai Barlev / Isatin-Schiff base-copper (II) complex induces cell death in p53-positive tumors // Cell Death Discovery, 4: 103 (2018)
DOI: 10.1038/s41420-018-0120-z
https://www.nature.com/articles/s41420-018-0120-z

(2018) Quartile Q1. Article.
2. Aleksei Titov, Alexey Petukhov, Alena Staliarova, Dmitriy Motorin, Emil Bulatov, Oleg Shuvalov, Surinder M. Soond, Mauro Piacentini, Gerry Melino, Andrey Zaritskey & Nickolai A. Barlev. The biological basis and clinical symptoms of CAR-T therapy-associated toxicites // Cell Death & Disease, 9, Article: 897 (2018)
Impact Factor = 6.187
DOI: 10.1038/s41419-018-0918-x
https://www.nature.com/articles/s41419-018-0918-x

(2018) Quartile Q2. Article.
3. Emil Bulatov, Aygul Valiullina, Regina Sayarova, Albert Rizvanov. Promising new therapeutic targets for regulation of inflammation and immunity: RING-type E3 ubiquitin ligases. Immunology Letters, 2018, 202, 44-51.
Impact Factor = 2.664
DOI: 10.1016/j.imlet.2018.08.001
https://www.sciencedirect.com/science/article/pii/S0165247817306077

(2018) Quartile Q1. Article.
4. Bulatov E, Zagidullin A, Valiullina A, Sayarova R, Rizvanov A. Small molecule modulators of RING-type E3 ligases: MDM and cullin families as targets // Frontiers in Pharmacology, 2018, 9, Article 450.
Impact Factor = 4.439
DOI: 10.3389/fphar.2018.00450
https://www.frontiersin.org/articles/10.3389/fphar.2018.00450/full
WOS:000431660700001

(2018) Quartile Q1. Article.
5. Vafina, G., Zainutdinova, E., Bulatov, E., Filimonova, M.N. Endonuclease from gram-negative bacteria Serratia marcescens is as effective as pulmozyme in the hydrolysis of DNA in sputum. // Frontiers in Pharmacology, 2018, 9, Article 114.
Impact Factor = 4.439
DOI: 10.3389/fphar.2018.00114
https://www.frontiersin.org/articles/10.3389/fphar.2018.00114/full
WOS:000425298100001

(2018)
Monography (27 pages).
6. Emil Bulatov. E3 ubiquitin ligases as targets for small molecule drug discovery: focus on Cullin RING family.
Глава в книге "Ubiquitin Proteasome System: A Review and Directions for Research". Hardcover edited collection (by selected invitation only). Nova Science Publishers, Inc., USA.
https://www.novapublishers.com/catalog/product_info.php?products_id=64423

(2018) Quartile Q2. Conference thesis.
7. Glagoleva, I., Kudriaeva, A., Belogurov, A., Rizvanov, A. and Bulatov, E. / Effect of Nutlin-3a, RG-7112, Carfilzomib and MG-132 on accumulation of p53 in eukaryotic HEK293 cell line // European Journal of Clinical Investigation, 2018, 48, 100
Impact Factor = 2.707
WOS:000434100200222
DOI: 10.1111/eci.12926

(2017) Quartile Q1. Conference thesis.
8. A. Valiullina, M. Gomzikova, T. Khaibullin, A. Rizvanov & E. Bulatov. Regulation of p53-dependent genes expression in multiple sclerosis: the effect of MDM2 inhibitor Nutlin-3a. // European Journal of Clinical Investigation, 2017, 47 (Suppl. 1), 141–142
Impact Factor = 2.714
DOI: 10.1111/eci.12749
https://kpfu.ru//staff_files/F1836875316/ESCI_141_142.pdf
WOS:000412099900326

(2017) Quartile Q1. Conference thesis.
9. Aygul Kh. Valiullina, Marina Gomzikova, Ekaterina E. Garanina, Timur Khaibullin, Albert Rizvanov, and Emil Bulatov. Small Molecule p53-MDM2 Inhibitors As Potential Regulators of p53-Dependent Genes Expression in Multiple Sclerosis. // Blood, 2017, 130:4820
Impact Factor = 13.164
http://www.bloodjournal.org/content/130/Suppl_1/4820

(2017) Quartile Q2. Conference thesis.
10. A. Valiullina, M. Gomzikova, T. Khaibullin, E. Garanina, E. Zmievskaya, A. Rizvanov, E. Bulatov. Effect of p53 activation on target gene expression and cytokine release in peripheral blood mononuclear cells. // Mol. Biol. Cell, 2017, vol. 28, no. 26, 545-546
Impact Factor = 3.685
DOI: 10.1091/mbc.E17-10-0618
https://kpfu.ru//staff_files/F_1215039000/2017ASCB_545_546.pdf

(2016) Quartile Q2. Conference thesis.

11. Валиуллина, А.Х., Саярова, Р.М., Соловьева, В.В., Ризванов, А.А., Булатов Э.Р. Изучение роли белков р53 и MDM2 в качестве потенциальных регуляторов аутоиммунных процессов при рассеянном склерозе. // Acta Naturae, 2016, спецвыпуск, том 2, с. 66
Impact Factor = 1.770
http://kpfu.ru//staff_files/F1913808647/2016_ActaNaturae_66.pdf

(2016) Quartile Q3. Article.
12. Vafina G, Bulatov E, Zaynutdinova E, Filimonova M. A One-Step Protocol for Chromatographic Purification of Non-recombinant Exogenous Bacterial Enzyme: Nuclease of Serratia marcescens // BioNanoScience. - 2016. - Vol.6, Is.4. - P.335-337.
CiteScore (Scopus) = 1.48
DOI: 10.1007/s12668-016-0226-9
https://link.springer.com/article/10.1007/s12668-016-0226-9
WOS:000390587700015

(2016) Quartile Q3. Article.
13. Bulatov, E., Khaiboullina, S, dos Reis, H.J., Palotás, A., Venkataraman, K., Vijayalakshmi, M., Rizvanov, A. Ubiquitin-Proteasome System: Promising Therapeutic Targets in Autoimmune and Neurodegenerative Diseases // BioNanoScience. - 2016. - Vol.6, Is.4. - P.341-344.
CiteScore (Scopus) = 1.48
DOI: 10.1007/s12668-016-0233-x
https://link.springer.com/article/10.1007/s12668-016-0233-x
WOS:000390587700017

(2016) Quartile Q2. Conference thesis.
14. P. Davidovich, R. Sayarova, A. Valiullina, V. Solovyeva, M. Gomzikova, A. Smirnov, A. Rizvanov,
E. Bulatov. Novel isatin-Schiff base copper (II) complexes as potential p53-activating pro-apoptotic agents. // Mol. Biol. Cell, 2016, 27:25, 3947, 708.
Impact Factor = 4.037
DOI: 10.1091/mbc.E16-10-0736
http://www.molbiolcell.org/content/suppl/2016/12/08/27.25.3947.DC1/2016ASCBMeeting-PosterAbstracts.pdf
WOS:000396047100121

(2016) Quartile Q1. Conference thesis.
15. Bulatov E., Valiullina A., Sayarova R., Rizvanov A. Inhibitors of MDM2 ubiquitin ligase as prospective modulators of autoimmunity // FEBS JOURNAL. - 2016. - Vol.283, Is.. - P.360-360.
Impact Factor = 4.237
DOI: 10.1111/febs.13808
http://onlinelibrary.wiley.com/doi/10.1111/febs.13808/epdf
WOS:000383616901715

(2015) Quartile Q1. Article.
16. Gadd, M. S., Bulatov, E. and Ciulli, A. Serendipitous SAD Solution for DMSO-Soaked SOCS2-ElonginC-ElonginB Crystals Using Covalently Incorporated Dimethylarsenic: Insights into Substrate Receptor Conformational Flexibility in Cullin RING Ligases. // PLoS ONE 2015, 10, e0131218.
Impact Factor = 3.234
DOI: 10.1371/journal.pone.0131218
WOS:000358150400086

(2015) Quartile Q1. Article.
17. Bulatov, E. and Ciulli, A. Targeting Cullin-RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation. // Biochem. J. 2015, 467, 365–386.
Impact Factor = 3.85
DOI: 10.1042/BJ20141450
WOS:000353217200002

(2015) Quartile Q1. Article.
18. Bulatov, E., Martin, E. M., Chatterjee, S., Knebel, A., Shimamura, S., Konijnenberg, A., Johnson, C., Zinn, N., Grandi, P., Sobott, F., Ciulli, A. Biophysical studies on interactions and assembly of full-size E3 ubiquitin ligase: suppressor of cytokine signaling 2 (SOCS2)-elongin BC-cullin 5-ring box protein 2 (RBX2). // J. Biol. Chem. 2015, 290, 4178–4191.
Impact Factor 2014 = 4.253
DOI: 10.1074/jbc.M114.616664
Article recommended by F1000Prime in Technical Advance category
WOS:000349458400029

Theses:
1. Emil Bulatov. PhD Thesis. Interactions, assembly and fragment screening of the multisubunit SOCS2-EloBC-Cul5-Rbx2 E3 ubiquitin ligase. University of Cambridge, UK, 2015.

2. Emil Bulatov. MPhil Thesis. Identification and Validation of a Series of P53-MDM2 and P53-MDMX Protein-protein Interaction Inhibitors. Newcastle University, UK, 2010.

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Ahmet Okay Caglayan

Turkey

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Rasoul Alikhani Koupaei

USA

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Atif Ahmed

USA

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Aaron Matthew Elliott

USA